Preprints
Filtering by Subject: Medicine and Health Sciences
Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progesterone and Spironolactone
Published: 2019-02-25
Subjects: Ecology and Evolutionary Biology, Evolution, Life Sciences, Medicine and Health Sciences, Other Medicine and Health Sciences
We report the analysis of activation by corticosteroids and progesterone of full-length mineralocorticoid receptor (MR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebrates. Based on their measured activities, aldosterone, cortisol, 11-deoxycorticosterone, corticosterone, 11-deoxcortisol, progesterone and 19-norprogesterone are potential physiological [...]
Cetacean morbillivirus, a journey from land to sea and viceversa
Published: 2019-01-15
Subjects: Immunology and Infectious Disease, Life Sciences, Medicine and Health Sciences, Microbiology, Virology
Cetacean Morbillivirus, the most relevant pathogen impacting the health and conservation of cetaceans worldwide, has shown in recent years an increased tendency to cross “interspecies barriers”, thereby giving rise to disease and mortality outbreaks in free-ranging dolphins and whales. This "Personal View" deals with the evolutionary “trajectories” of this viral pathogen, likely originating from [...]