Functional coherence among miRNA targets: a potential metric for assessing biological signal among target prediction methods in non-model species

This is a Preprint and has not been peer reviewed. This is version 3 of this Preprint.

Add a Comment

You must log in to post a comment.


Comments

There are no comments or no comments have been made public for this article.

Downloads

Download Preprint

Authors

Christopher Wheat , Rachel A. Steward, Yu Okamura, Heiko Vogel, Philipp Lehmann, Kevin T. Roberts

Abstract

Although miRNA regulation of protein production is a likely target of adaptive evolution, high false-positive rates in the identification of mRNAs targeted by miRNAs in non-model species’ complicates interpretation of recent advances. Here we document the challenges and then outline steps for the community to address these challenges.

DOI

https://doi.org/10.32942/X2PK7B

Subjects

Biology, Ecology and Evolutionary Biology, Life Sciences

Keywords

miRNA, target detection, false-positives, functional coherence, gene set enrichment analysis

Dates

Published: 2023-11-30 03:36

Last Updated: 2023-11-30 08:36

Older Versions
License

CC-By Attribution-NonCommercial-NoDerivatives 4.0 International

Additional Metadata

Language:
English

Conflict of interest statement:
None

Data and Code Availability Statement:
Open data/code are not available, will be made available upon publication