Preprints
There are 2687 Preprints listed.
Antechodynamics and Antechokinetics: Dynamics and Kinetics of Antibiotic Resistance Molecules
Published: 2024-12-17
Subjects: Life Sciences, Medicine and Health Sciences
Pharmacology of antimicrobial drugs comprises pharmacodynamics (PD) and pharmacokinetics (PK). PD refers to studying drugs' mode of action at different concentrations on their molecular targets and the resulting effect(s). PK refers to studying the way(s) by which drugs enter and are distributed to reach their targets in different compartments (such as tissues in the body) and how the local drug [...]
Simple maternal effect animal models may provide biased estimates of additive genetic and maternal variation
Published: 2024-12-17
Subjects: Ecology and Evolutionary Biology, Genetics, Zoology
Maternal effects (the consistent effect of a mother on her offspring) can inflate estimates of additive genetic variation (\Va) if not properly accounted for. As they are typically assumed to cause similarities only among maternal siblings, they are often accounted for by modelling maternal identity effects. However, if maternal effects have a genetic basis, they create additional similarities [...]
Unlocking the hidden dimensions of genomic diversity within species
Published: 2024-12-17
Subjects: Evolution, Genomics, Molecular Biology
The missing heritability problem, defined as the failure of genetic variants to explain variance in phenotypes, has been an unsolved issue in genetics for the past two decades. A potential solution to this problem stems from the idea that single nucleotide polymorphisms and copy-number variants, the most commonly studied forms of genomic diversity, do not represent the totality of the information [...]
Laguna Beach Nearshore Giant Kelp and Bryozoan
Published: 2024-12-14
Subjects: Physical Sciences and Mathematics
This paper examines the scattered nearshore kelp beds in Laguna Beach subtidal shallow rock reef substrate between Brooks Street and Thalia Street, referred to as town. The nearshore kelp is approximately 200 meters from the shore. This area has been protected since 2012 when it was considered a California Marine Protected Area (MPA) and classified as Laguna Beach State Marine Reserve (LBSMR). [...]
Antlions (Myrmeleontidae) in the Doñana National Park
Published: 2024-12-14
Subjects: Life Sciences
This study represents the first comprehensive survey of antlions (Myrmeleontidae) in Doñana National Park, conducted across 58 sampling locations during two field seasons (April–June 2023 and March–July 2024). A total of 12 species from 9 genera were identified, with 406 larval-stage specimens collected, of which 295 successfully emerged as adults (201 females and 94 males, including 28 imagos [...]
Gut microbiome communities demonstrate fine-scale spatial variation in a closed, island bird population
Published: 2024-12-14
Subjects: Life Sciences
Environmental variation is a key factor shaping microbiome communities in wild animals. However, most studies have focussed on separate populations distributed over large spatial scales. How ecological factors shape inter-individual microbiome variation within a single landscape and host population remains poorly understood. Here, we use dense sampling of individuals in a natural, closed [...]
Pleistocene climatic changes drive expansion and fragmentation in a widespread arid zone specialist, Petrogale lateralis
Published: 2024-12-13
Subjects: Ecology and Evolutionary Biology
Organisms living in arid biomes are predicted to be at threat of extinction associated with ongoing climatic and anthropogenic change. Our understanding of species responses to Pleistocene climatic changes within these environments is still limited, particularly in Australia. Here we evaluate the demographic and evolutionary history of a widespread Australian marsupial, the black-footed [...]
Foundations and future directions for causal inference in ecological research
Published: 2024-12-13
Subjects: Ecology and Evolutionary Biology
Ecology often seeks to answer causal questions, and while ecologists have a rich history of experimental approaches, novel observational data streams and the need to apply insights across naturally occurring conditions pose opportunities and challenges. Other fields have developed causal inference approaches that can enhance and expand our ability to answer ecological causal questions using [...]
A bottom-up mammoth population model predicts moderate densities and high vulnerability to hunting
Published: 2024-12-13
Subjects: Ecology and Evolutionary Biology, Paleobiology
During the last glacial, large grazers inhabited Eurasia’s mammoth steppe. This cold steppe was productive enough to sustain a diverse assemblage of large mammals, but it remains controversial which population densities it could support. In sufficient densities, large herbivores can act as ecosystem engineers: creating and maintaining grassland habitat by means of disturbance and accelerated [...]
Community herbivory in tropical montane rainforests is affected by phylogenetic plant diversity, specific leaf area, and leaf nutrient concentrations
Published: 2024-12-13
Subjects: Life Sciences
Arthropod herbivores modulate ecosystem structure, productivity, and nutrient cycling. While previous work has shown that plant-herbivore interactions for individual species are shaped by abiotic factors, traits, and the surrounding plant community, the relative contribution of abiotic and biotic factors for herbivory at the community level remains elusive. Here, we use a structural equation [...]
Global patterns of insect herbivory across forest canopies and understories: Insights from a tropical case study and a global comparison
Published: 2024-12-12
Subjects: Life Sciences
Several studies have examined global patterns of insect herbivory, revealing variations with latitude, elevation, and temperature. However, less attention has been given to herbivory patterns at smaller spatial scales, particularly the comparison between forest canopies and understories. Understanding these finer-scale patterns is crucial for predicting ecological responses to both natural and [...]
Greenspace modifies the associations between heat and mortality: A systematic review and meta-analysis of observational studies
Published: 2024-12-12
Subjects: Medicine and Health Sciences
Greenspace has been increasingly examined for its potential associations with heat-related mortality. However, quantitative synthesis of evidence on this association remains limited. We conducted a systematic review and meta-analysis of observational studies published through July 20, 2025, examining the relationship between effect modification of greenspace on heat-related mortality risk. We [...]
The Development and Evolution of Arthropod Tagmata
Published: 2024-12-11
Subjects: Biology, Cell and Developmental Biology, Developmental Biology, Ecology and Evolutionary Biology, Entomology, Evolution, Integrative Biology, Life Sciences
The segmented body plan is a hallmark of the arthropod body plan. Morphological segments are formed during embryogenesis, through a complex procedure involving the activation of a series of gene regulatory networks. The segments of the arthropod body are organized into functional units known as tagmata, and these tagmata are different among the arthropod classes (e.g. head, thorax and abdomen in [...]
iNaturalist as a platform for documenting Chilean funga
Published: 2024-12-09
Subjects: Biodiversity, Environmental Policy, Life Sciences, Other Life Sciences
This study analyzes the impact of iNaturalist on the recording and documentation of fungi in Chile from 2008 to 2024, highlighting its role in integrating citizen science into biodiversity monitoring. This community effort—which currently totals more than 63,000 observations representing 1,245 species—is concentrated in the central and southern regions of the country, mainly in urban areas, where [...]
Microbes as conservation targets
Published: 2024-12-09
Subjects: Life Sciences
A world without microorganisms would lack essential processes that support life. The degradation or loss of microbiomes will lead to severe disruptions in ecosystems, nutrient cycling, and the climate; failures in food production; and crises in animal and human health. Yet, microbes remain largely excluded from nature conservation efforts. Current microbial management predominantly relies on the [...]