Preprints
Filtering by Subject: Biochemistry
In-silico evaluation of aspartate therapy for lactic acidosis in Alligator mississippiensis
Published: 2026-06-23
Subjects: Biochemistry, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Computational Biology, Systems and Integrative Physiology Life Sciences
Hyperlactatemia, and/or lactic acidosis, is a common complication in wildlife due to the sensitivity of these species to capture induce complications. The treatment of lactic acidosis in humans is equally as controversial as in veterinary medicine. Stabilisation of blood pH during lactic acidosis is difficult to achieve. Crocodilians, such as the American Alligator (Alligator mississippiensis), [...]
Abiogenesis as the origin of adaptive evolution. An alternative to the Oparin-Haldane model
Published: 2025-02-18
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Computational Biology, Evolution, Molecular Biology, Molecular Genetics, Other Ecology and Evolutionary Biology, Population Biology, Systems and Integrative Physiology Life Sciences, Systems Biology
The emergence of life from non-living matter remains one of the most profound unresolved questions in natural philosophy. Current paradigms largely inherit the Oparin-Haldane assumption that abiogenesis is preceded by a prolonged accumulation of traits through both nonadaptive (e.g. self-organisation) and adaptive (i.e. natural selection) processes. Yet this raises a legitimate question: how can [...]
Faster than expected: Release of nitrogen and phosphorus from decomposing wood
Published: 2024-04-12
Subjects: Biochemistry, Forest Biology, Other Plant Sciences
● Deadwood represents globally important carbon, nitrogen, and phosphorus pools. Current wood nutrient dynamics models are extensions of those developed for leaf litter decomposition. However, tissue structure and dominant decomposers differ between deadwood and litter, and recent evidence suggests that decomposer stoichiometry in combination with litter quality may affect nutrient [...]
A rapidly expanding house of cards: the silent loss of cell physiology hampers marine biosciences
Published: 2021-11-22
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Life Sciences, Marine Biology, Physiology, Systems and Integrative Physiology Life Sciences
Perspective: An ongoing loss of expertise on the biochemistry and physiology of marine organisms hampers our understanding of biological mechanisms upon rapidly growing “-omics” approaches reply -ultimately affecting our ability to predict organismal responses to climate change.
Computational Modeling and Evolutionary Implications of Biochemical Reactions in Bacterial Microcompartments
Published: 2021-09-23
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Biology, Life Sciences
Bacterial microcompartments (BMCs) are protein-encapsulated compartments found across at least 23 bacterial phyla. BMCs contain a variety of metabolic processes that share the commonality of toxic or volatile intermediates, oxygen-sensitive enzymes and cofactors, or increased substrate concentration for magnified reaction rates. These compartmentalized reactions have been computationally modeled [...]
Ecosystem services of a functionally diverse riparian zone in the Amazon–Cerrado agricultural frontier
Published: 2019-08-21
Subjects: Agronomy and Crop Sciences Life Sciences, Biochemistry, Biochemistry, Biophysics, and Structural Biology, Biodiversity, Botany, Ecology and Evolutionary Biology, Forest Sciences, Life Sciences, Plant Sciences, Terrestrial and Aquatic Ecology
The ecological services provided by protected riparian zones in human-altered landscapes are widely acknowledged, yet little is known about them. In this study, we assess ecosystem properties that a protected riparian zone maintains in contrast to environmental changes in its surroundings caused by agro-industrial activities in the northwestern fringe of the Brazilian Cerrado on the [...]