This is a Preprint and has not been peer reviewed. The published version of this Preprint is available: https://doi.org/10.1016/j.mib.2021.10.001. This is version 1 of this Preprint.
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Bacterial microcompartments (BMCs) are protein-encapsulated compartments found across at least 23 bacterial phyla. BMCs contain a variety of metabolic processes that share the commonality of toxic or volatile intermediates, oxygen-sensitive enzymes and cofactors, or increased substrate concentration for magnified reaction rates. These compartmentalized reactions have been computationally modeled to explore the encapsulated dynamics, ask evolutionary-based questions, and develop a more systematic understanding required for the engineering of novel BMCs. Many crucial aspects of these systems remain unknown or unmeasured, such as substrate permeabilities across the protein shell, feasibility of pH gradients, and transport rates of associated substrates into the cell. This review explores existing BMC models, dominated in the literature by cyanobacterial carboxysomes, and highlights potentially important areas for exploration.
Biochemistry, Biochemistry, Biophysics, and Structural Biology, Biology, Life Sciences
Bacterial Microcompartments, carbon fixation, Carboxysome, CCM, Metabolosome, model, oxygen, photosynthesis, Rubisco
Published: 2021-09-23 10:02
Conflict of interest statement:
J.C.C. has equity and is co-founder and Chief Science Advisor for Prometheus Materials Inc. All other authors declare no competing interests.