Filtering by Subject: Biochemistry, Biophysics, and Structural Biology

From eggs to adulthood: sustained effects of early developmental temperature and corticosterone exposure on physiology and body size in an Australian lizard

Ondi Crino, Kristoffer H Wild, Christopher R. Friesen, et al.

Published: 2024-06-28
Subjects: Biochemistry, Biophysics, and Structural Biology, Biology, Integrative Biology, Life Sciences, Other Ecology and Evolutionary Biology

As global temperatures continue to rise due to climate change, developing animals may be increasingly exposed to elevated temperatures. Additionally, elevated temperatures could affect developing animals through indirect effects such as increased exposure to maternal glucocorticoid hormones. Exposure to elevated levels of glucocorticoids during development can have immediate and sustained effects [...]

CasPEDIA Database: A Functional Classification System for Class 2 CRISPR-Cas Enzymes

Benjamin A Adler, Marena I Trinidad, Daniel Bellieny-Rabelo, et al.

Published: 2023-08-17
Subjects: Biochemistry, Biophysics, and Structural Biology, Bioinformatics, Life Sciences

CRISPR-Cas enzymes enable RNA-guided bacterial immunity and are widely used for biotechnological applications including genome editing. In particular, the Class 2 CRISPR-associated enzymes (Cas9, Cas12 and Cas13 families), have been deployed for numerous research, clinical and agricultural applications. However, the immense genetic and biochemical diversity of these proteins in the public domain [...]

A rapidly expanding house of cards: the silent loss of cell physiology hampers marine biosciences

Frank Melzner, Imke Podbielski, Felix C Mark, et al.

Published: 2021-11-22
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Life Sciences, Marine Biology, Physiology, Systems and Integrative Physiology Life Sciences

Perspective: An ongoing loss of expertise on the biochemistry and physiology of marine organisms hampers our understanding of biological mechanisms upon rapidly growing “-omics” approaches reply -ultimately affecting our ability to predict organismal responses to climate change.

Computational Modeling and Evolutionary Implications of Biochemical Reactions in Bacterial Microcompartments

Clair A. Huffine, Lucas C Wheeler, Boswell Wing, et al.

Published: 2021-09-23
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Biology, Life Sciences

Bacterial microcompartments (BMCs) are protein-encapsulated compartments found across at least 23 bacterial phyla. BMCs contain a variety of metabolic processes that share the commonality of toxic or volatile intermediates, oxygen-sensitive enzymes and cofactors, or increased substrate concentration for magnified reaction rates. These compartmentalized reactions have been computationally modeled [...]

Impact of Infectious Disease on Humans and Our Origins

Petar Gabrić

Published: 2021-06-18
Subjects: Anthropology, Archaeological Anthropology, Arts and Humanities, Bacteriology, Biochemistry, Biophysics, and Structural Biology, Biological and Physical Anthropology, Biological Phenomena, Cell Phenomena, and Immunity, Cell and Developmental Biology, Cell Biology, Ecology and Evolutionary Biology, Evolution, Genetic Phenomena, Genetics, Genetics and Genomics, History of Art, Architecture, and Archaeology, Life Sciences, Medical Biochemistry, Medical Cell Biology, Medical Genetics, Medical Immunology, Medical Microbiology, Medical Molecular Biology, Medical Pathology, Medical Sciences, Medicine and Health Sciences, Microbiology, Molecular Biology, Molecular Genetics, Pathogenic Microbiology, Pharmacology, Pharmacology, Toxicology and Environmental Health, Social and Behavioral Sciences, Virology

On May 16, 2020, the Center for Academic Research and Training in Anthropogeny organized the symposium “Impact of Infectious Disease on Humans and Our Origins”. The symposium aimed to gather experts on infectious diseases in one place and discuss the interrelationship between different pathogens and humans in an evolutionary context. The talks discussed topics including SARS-CoV-2, dengue and [...]

Epicuticular compounds of Protopiophila litigata (Diptera: Piophilidae): identification and sexual selection across two years in the wild

Christopher Angell, Sharon Curtis, Anaïs Ryckenbusch, et al.

Published: 2020-03-18
Subjects: Behavior and Ethology, Biochemistry, Biophysics, and Structural Biology, Ecology and Evolutionary Biology, Entomology, Evolution, Life Sciences

The epicuticular compounds (ECs) of insects serve both to waterproof the cuticle and, in many taxa, as pheromones that are important for various social interactions including mate choice within populations. However, ECs have not been individually identified in many species and most studies of their role in mate choice have been performed in a laboratory setting. Here we newly identify and [...]

Ecosystem services of a functionally diverse riparian zone in the Amazon–Cerrado agricultural frontier

Rodolfo Luiz Bezerra Nóbrega, Taciana Ziembowicz, Gilmar N. Torres, et al.

Published: 2019-08-21
Subjects: Agronomy and Crop Sciences Life Sciences, Biochemistry, Biochemistry, Biophysics, and Structural Biology, Biodiversity, Botany, Ecology and Evolutionary Biology, Forest Sciences, Life Sciences, Plant Sciences, Terrestrial and Aquatic Ecology

The ecological services provided by protected riparian zones in human-altered landscapes are widely acknowledged, yet little is known about them. In this study, we assess ecosystem properties that a protected riparian zone maintains in contrast to environmental changes in its surroundings caused by agro-industrial activities in the northwestern fringe of the Brazilian Cerrado on the [...]

Steroid Receptors and Vertebrate Evolution

Michael Baker

Published: 2019-03-29
Subjects: Biochemistry, Biophysics, and Structural Biology, Biology, Ecology and Evolutionary Biology, Evolution, Life Sciences

Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone, cortisol), and sex steroids (estrogen, [...]

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