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Remote extracellular attacks on bacteriophage

Remote extracellular attacks on bacteriophage

This is a Preprint and has not been peer reviewed. This is version 4 of this Preprint.

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Authors

Lisa Freund, Marie Vasse , Gregory J. Velicer

Abstract

Bacteriophages and their hosts co-evolve while exploiting and defending against the other, respectively. Anti-phage defences generally prevent attachment to cells or post-injection replication; variation in such defences shapes phage host range. While investigating the host range of the virulent myxophage Mx1 among natural-isolate strains of the social bacterium Myxococcus xanthus, we found that most strains render large majorities (>99%) of free phage particles non-viable – unable to infect a permissive host. Culture supernatants from all inactivating strains neutralized free phage, implicating diffusible anti-phage compounds, alth...  more

DOI

https://doi.org/10.32942/X28S35

Subjects

Ecology and Evolutionary Biology, Life Sciences

Keywords

bacterial immunity, anti-phage defence, host-pathogen interactions, myxobacteria, public good, virus-host interactions

Dates

Published: 2023-10-15 01:11

Last Updated: 2025-06-13 18:56

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License

CC-By Attribution-NonCommercial-NoDerivatives 4.0 International

Additional Metadata

Language:
English