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Resolving large-scale genome evolution in the high-throughput sequencing era: structural variants, genome rearrangement, and karyotype dynamics in animals
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Abstract
Genomic structural variation, genomic rearrangements and karyotype variants are important components on which evolution acts in addition to single nucleotide variants, which are the most common type of variant being studied since the rise of next generation sequencing. These variants have unique mutational mechanisms and evolutionary consequences compared to single nucleotide variants. Here we review the history and methods used to study genomic structural variants in animals, including technical challenges of current methods and promising new approaches. We then review case studies to illustrate how large genomic variants can drive interesti... more
DOI
https://doi.org/10.32942/X2J59Q
Subjects
Life Sciences
Keywords
evolution, supergenes, recombination, karyotypic variants, genomic rearrangements, Supergenes, recombination, Karyotypic variants, Genomic rearrangements
Dates
Published: 2023-05-05 18:53
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English
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