Alternative reading frames are an underappreciated source of protein sequence novelty

This is a Preprint and has not been peer reviewed. This is version 1 of this Preprint.

Downloads

Download Preprint

Authors

Zachary Ardern 

Abstract

Alternative reading frames of protein coding genes are a major contributor to the evolution of novel protein products. Recent studies demonstrating this include examples across the three domains of cellular life and in viruses. Alternative frame sequences both increase the number of trials available for the evolutionary invention of new genes and have unusual properties which may facilitate gene origin. The structure of the standard genetic code contributes to the features and gene-likeness of some alternative frame sequences. These findings have important implications across diverse areas of molecular biology, including for genome annotation, structural biology, and evolutionary genomics.

DOI

https://doi.org/10.32942/X2G01B

Subjects

Ecology and Evolutionary Biology, Evolution, Genetics and Genomics, Genomics, Life Sciences

Keywords

de novo gene origin, frameshifting, genetic code, overlapping genes, alternative frame sequences

Dates

Published: 2022-12-05 04:34

License

CC-BY Attribution-No Derivatives 4.0 International

Additional Metadata

Data and Code Availability Statement:
Not applicable

Add a Comment

You must log in to post a comment.


Comments

There are no comments or no comments have been made public for this article.