Preprints
Filtering by Subject: Systems and Integrative Physiology Life Sciences
Toxin resistance mechanisms span biological scales in the Royal Ground Snake (Colubridae: Erythrolamprus reginae)
Published: 2025-06-13
Subjects: Animal Sciences, Behavior and Ethology, Biology, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Ecology and Evolutionary Biology, Evolution, Genomics, Integrative Biology, Life Sciences, Molecular Biology, Neuroscience and Neurobiology, Physiology, Systems and Integrative Physiology Life Sciences, Systems Biology, Zoology
Exposure to multiple toxic compounds imposes diverse selective pressures, potentially leading to a toxin-resistant phenotype that operates across biological levels. There are several known toxin resistance mechanisms–such as behavioral avoidance, metabolic detoxification, and target-site insensitivity. However, most studies have been conducted with exposure to a single toxin or have focused on [...]
A framework for modelling thermal load sensitivity across life
Published: 2025-06-01
Subjects: Ecology and Evolutionary Biology, Integrative Biology, Life Sciences, Physiology, Systems and Integrative Physiology Life Sciences
Forecasts of vulnerability to climate warming require an integrative understanding of how species are exposed to, are damaged by, and recover from thermal stress in natural environments. The sensitivity of species to temperature depends on the frequency, duration, and magnitude of thermal stress. Thus, there is a generally recognised need to move beyond physiological metrics based solely on [...]
On the feasibility of nonadaptive, nonsequential abiogenesis
Published: 2025-02-18
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Computational Biology, Evolution, Molecular Biology, Molecular Genetics, Other Ecology and Evolutionary Biology, Population Biology, Systems and Integrative Physiology Life Sciences, Systems Biology
The emergence of life from non-living matter remains one of the most profound unresolved questions in natural philosophy. Classical models derived from the Oparin-Haldane hypothesis assume a gradual (sequential), selective assembly of biological precursors. Yet, for more than a century, all experimental efforts in this direction have failed in their attempt to achieve material abiogenesis. May be [...]
The Deadly Trio: Do warming, acidification & deoxygenation destabilize the anemone-algae symbiosis?
Published: 2024-11-04
Subjects: Integrative Biology, Life Sciences, Marine Biology, Physiology, Systems and Integrative Physiology Life Sciences
Anthropogenic climate change is primarily driven by carbon dioxide release, which causes a domino effect of warming, acidification, and hypoxia in aquatic habitats. Using a fully-crossed experimental design, we investigated how exposure to this “deadly trio” of environmental stressors affects the sea anemone, Exaiptasia diaphana and its endosymbiotic dinoflagellates. To mimic conditions found on [...]
A rapidly expanding house of cards: the silent loss of cell physiology hampers marine biosciences
Published: 2021-11-22
Subjects: Biochemistry, Biochemistry, Biophysics, and Structural Biology, Cellular and Molecular Physiology, Comparative and Evolutionary Physiology, Life Sciences, Marine Biology, Physiology, Systems and Integrative Physiology Life Sciences
Perspective: An ongoing loss of expertise on the biochemistry and physiology of marine organisms hampers our understanding of biological mechanisms upon rapidly growing “-omics” approaches reply -ultimately affecting our ability to predict organismal responses to climate change.