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Preprints

Filtering by Subject: Microbiology

Composite virulence: useful metric or conceptual trap?

Luis M. Silva, Tiago G. Zeferino

Published: 2026-02-20
Subjects: Animal Diseases, Animal Experimentation and Research, Animal Sciences, Biodiversity, Biology, Ecology and Evolutionary Biology, Evolution, Immunity, Immunology and Infectious Disease, Immunology of Infectious Disease, Immunopathology, Life Sciences, Medical Microbiology, Microbiology, Other Ecology and Evolutionary Biology, Other Immunology and Infectious Disease, Parasitic Diseases, Parasitology, Pathogenic Microbiology, Plant Pathology, Research Methods in Life Sciences, Zoology

Virulence, the harm an infection causes to its host, is a cornerstone concept in ecology and evolution, yet it remains difficult to quantify because infection impact is multidimensional, dynamic, and context-dependent. Infections can reduce host performance through multiple, partially redundant routes (including mortality, fecundity loss, behavioural impairment, and physiological disruption), [...]

Anergiobiosis: a testable framework for microbial life under extreme power limitation

Paul Carini, Roland Hatzenpichler, Jennifer F Biddle

Published: 2026-02-20
Subjects: Biology, Life Sciences, Marine Biology, Microbiology

"Aeonophily" was recently suggested as a new category of extremophily for ultra-slow-growing subsurface microorganisms. This terminology conflates a physiological state with potential extremophilic specialization. We propose "anergiobiosis" to describe life without sufficient power to sustain cell division, separating this state from questions about specialization. Analogous to temperature [...]

Interplay of diet, heat stress, and the microbiome shapes health and escape behavior in amphibian larvae

Paula Cabral Eterovick, Julian Glos, Franziska Burkart, et al.

Published: 2026-02-11
Subjects: Behavior and Ethology, Ecology and Evolutionary Biology, Microbiology, Organismal Biological Physiology

What animals eat modulates their microbiome and is fundamental to their health. Microbiomes can improve hosts’ ability to cope with environmental stressors, including increased temperatures and altered food quantity and quality associated with climate change. Using a multifactorial experimental design, we tested whether three diets with increasing amounts of protein, fat, and components of animal [...]

Biochar–Microbial Synergistic Systems for Nitrogen and Phosphorus Removal in Polluted Waters: Mechanisms, Studies, and Insights

Tianqi Zhu, Di Liu

Published: 2025-12-11
Subjects: Environmental Engineering, Microbiology, Terrestrial and Aquatic Ecology

Eutrophication caused by increasing non-point source pollution has resulted in the accumulation of nitrogen and phosphorus in water bodies, leading to severe algal blooms, oxygen depletion, and ecosystem degradation. However, conventional remediation technologies often face limitations in efficiency and sustainability. Biochar, derived from organic waste, has gained attention for its strong [...]

Beneath the Pavement: Understanding mycorrhizal fungi in urban ecosystems and the path forward

Kelsey R. Patrick, Nicholas Medina, Natalie Rodriguez, et al.

Published: 2025-11-03
Subjects: Biodiversity, Biology, Ecology and Evolutionary Biology, Environmental Microbiology and Microbial Ecology Life Sciences, Environmental Studies, Human Ecology, Life Sciences, Microbiology, Social and Behavioral Sciences, Urban Studies and Planning

Urban expansion is reshaping ecosystems worldwide, yet the responses of mycorrhizal fungi—key mediators of plant–soil interactions—remain poorly understood. In this review, we synthesize current knowledge on the environmental and ecological factors shaping mycorrhizal fungal diversity, distribution, and function in cities. We highlight how greenspace and landscape features—including plant [...]

Microplastic interference influences Pseudomonas fluorescens in denitrification efficiency of wastewater treatment

Varda Qudratullah

Published: 2025-10-28
Subjects: Ecology and Evolutionary Biology, Microbiology, Pharmacology, Toxicology and Environmental Health

Wastewater treatment plants (WWTP) play an essential role in pathogen and contaminant removal in wastewater. While developed countries treat approximately 70% of industrial wastewater prior to discharge, only about 8% is treated in developing countries. WWTP solutions can reduce the solids load, including microplastics, by up to 98.4%. Still, it is estimated that about 65 million microplastics [...]

Bridging the scales: what can microbial ecologists learn from classic ecology?

Luca Beldi, Alyssa Henderson, Megan N. Y. Lee, et al.

Published: 2025-06-30
Subjects: Ecology and Evolutionary Biology, Environmental Microbiology and Microbial Ecology Life Sciences, Microbiology

The fields of ecology and microbiology have historically developed independently of one another, resulting in each having unique methods, terminology, and concepts. Microbial ecology aims to synthesise these perspectives, merging the molecular and reductionist strengths of the microbiologist with the systems-level viewpoint of the ecologist. However, unifying disciplines with independent [...]

Two Metschnikowia nectar yeast species have similar volatile profiles, but elicit differential foraging in bee pollinators

M. Elizabeth Moore, Lindsey Wilson, Nathan Brandt, et al.

Published: 2025-06-18
Subjects: Ecology and Evolutionary Biology, Entomology, Life Sciences, Microbiology, Organismal Biological Physiology, Other Microbiology

Nectar yeasts are a highly specialized group of fungi that may play key roles in pollination ecology. Nectar yeasts lack an independent dispersal mechanism to access new habitats with fresh resources. Yeasts, bumble bee pollinators, and flowering plants likely take part in a series of diffuse mutualisms, wherein yeast attract bees that provide phoretic travel between flowers. This interaction [...]

Elevating the importance of Risk of Bias assessment for ecology and evolution

Antica Culina, Dugald Foster, Matthew Grainger, et al.

Published: 2025-06-16
Subjects: Agriculture, Animal Sciences, Biodiversity, Biology, Ecology and Evolutionary Biology, Entomology, Life Sciences, Marine Biology, Microbiology, Plant Sciences, Research Methods in Life Sciences

Systematic reviews and meta-analyses are key evidence synthesis methods informing research and policy. An assessment of the Risk of Bias (RoB) in included studies is normally considered an essential component of these. However, RoB assessment is rare in ecology and evolutionary biology (EEB), and tools from other fields are seldom adopted. To identify reasons for this limited uptake, we surveyed [...]

Applying Evolutionary Theory to Understand Host-Microbiome Evolution: New Tricks for Old Dogs

Bob Week, Shelbi L. Russel, Hinrich Schulenburg, et al.

Published: 2024-11-27
Subjects: Ecology and Evolutionary Biology, Microbiology

All plants and animals are host to a community of microorganisms, their microbiomes, that have crucial influences on the life history and performance of their hosts. Despite the importance of such host-microbiome relationships, relatively little is known about the role microbiomes play in mediating evolution of the host as well as entire host-microbe assemblages. This knowledge gap is partly due [...]

Gut microbiome composition and function – including transposase gene abundance - varies with age, but not senescence, in a wild vertebrate

Chuen Zhang Lee, Sarah F Worsley, Charli S. Davies, et al.

Published: 2024-11-14
Subjects: Bioinformatics, Ecology and Evolutionary Biology, Life Sciences, Microbiology, Ornithology

Studies on wild animals, mostly undertaken using 16S metabarcoding, have yielded ambigous evidence regarding changes in the gut microbiome (GM) with age and senescence. Furthermore, variation in GM function has rarely been studied in such wild populations, despite GM metabolic characteristics potentially being associated with host senescent declines. Here, we used seven years of longitudinal [...]

Evolutionarily Optimal Phage Life-History Traits

Joan Roughgarden

Published: 2024-11-09
Subjects: Ecology and Evolutionary Biology, Evolution, Life Sciences, Microbiology, Population Biology

Optimal phage life-history traits are computed from data on phenotypic tradeoffs presented in De Paepe and Tadei (2006). A parameter is introduced, l_e, that describes the loss of virions in the environment. Hygienic interventions increase l_e. The optimal burst size decreases with l_e and the optimal capsid thickness increases with l_e. The optimal viral fitness also decreases with l_e. An [...]

Coexistence theory for microbial ecology, and vice versa

James A. Orr, David W Armitage, Andrew D Letten

Published: 2024-10-21
Subjects: Ecology and Evolutionary Biology, Microbiology

Classical models from theoretical ecology are seeing increasing uptake in microbial ecology, but there remains rich potential for closer cross-pollination. Here we explore opportunities for stronger integration of ecological theory into microbial research (and vice versa) through the lens of so-called "modern" coexistence theory. Coexistence theory encompasses a body of theory for disentangling [...]

Should I stay or should I go: Transmission trade-offs in mobile genetic elements

Jana Sanne Huisman, Andrina Bernhard, Claudia Igler

Published: 2024-10-16
Subjects: Biology, Ecology and Evolutionary Biology, Life Sciences, Microbiology

Mobile genetic elements (MGEs), including temperate bacteriophages and conjugative plasmids, are major vectors of virulence and antibiotic resistance in bacterial populations. To maximize reproductive fitness, MGEs have to optimize horizontal and vertical transmission. Yet, the cost of horizontal transmission (e.g. phage lysis) puts these transmission modes at odds. Using virulence-transmission [...]

Microbial functional diversity and redundancy: moving forward

Pierre Ramond, Pierre Galand, Ramiro Logares

Published: 2024-07-04
Subjects: Biodiversity, Ecology and Evolutionary Biology, Microbiology

Microbial functional ecology is expanding as we can now measure the traits of wild microbes that affect ecosystem functioning. Here, we review techniques and advances that could be the bedrock for a unified framework to study microbial functions. We then explore the technical, ecological, and evolutionary processes that could explain environmental patterns of microbial functional diversity and [...]

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