Preprints

Filtering by Subject: Pharmacology, Toxicology and Environmental Health

Spillover of human antivirals may promote resistant pathogens in animal reservoirs

Emma J. Rosi, Jerker B. Fick, Barbara Han

Published: 2022-09-12
Subjects: Ecology and Evolutionary Biology, Environmental Health Life Sciences, Immunology and Infectious Disease, Life Sciences, Other Immunology and Infectious Disease, Pharmacology, Toxicology and Environmental Health, Terrestrial and Aquatic Ecology

Novel viral pathogens are causing diseases to emerge in humans, a challenge to which society has responded with technological innovations such as antiviral therapies. Antivirals can be rapidly deployed to mitigate severe disease, and with vaccines, save human lives and provide a long-term safety net against new viral diseases. Yet with these advances come unforeseen consequences when antivirals [...]

The promise of an evolutionary perspective of alcohol consumption

Hans Hofmann, Benjamin Clites, Jonathan Pierce

Published: 2022-08-23
Subjects: Ecology and Evolutionary Biology, Life Sciences, Medicine and Health Sciences, Neuroscience and Neurobiology, Other Ecology and Evolutionary Biology, Other Life Sciences, Pharmacology, Toxicology and Environmental Health

The urgent need for medical treatments of alcohol use disorders has motivated the search for novel molecular targets of alcohol response. Most studies exploit the strengths of lab animals without considering how these and other species may have adapted to respond to alcohol in an ecological context. Here, we provide an evolutionary perspective on the molecular and genetic underpinnings of alcohol [...]

A review of chemical defense in harlequin toads (Bufonidae; Atelopus)

Kannon Pearson, Rebecca Tarvin

Published: 2021-11-29
Subjects: Ecology and Evolutionary Biology, Evolution, Life Sciences, Other Ecology and Evolutionary Biology, Other Pharmacology, Toxicology and Environmental Health, Pharmacology, Toxicology and Environmental Health

Toads of the genus Atelopus are chemically defended by a unique combination of endogenously synthesized cardiotoxins (bufadienolides) and neurotoxins which may be sequestered (guanidinium alkaloids). Investigation into Atelopus small-molecule chemical defenses has been primarily concerned with identifying and characterizing various forms of these toxins while largely overlooking their ecological [...]

Thermal processing reduces PFAS concentrations in blue food – A systematic review and meta-analysis

Catharina Vendl, Patrice Pottier, Matthew D. Taylor, et al.

Published: 2021-11-10
Subjects: Environmental Health Life Sciences, Life Sciences, Pharmacology, Toxicology and Environmental Health, Toxicology

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment and often ingested with food. PFAS exposure in people can have detrimental health consequences. Therefore, reducing PFAS burdens in food items is of great importance to public health. Here, we investigated whether cooking reduces PFAS concentrations in animal-derived food products by synthesizing experimental studies. [...]

Impact of Infectious Disease on Humans and Our Origins

Petar Gabrić

Published: 2021-06-19
Subjects: Anthropology, Archaeological Anthropology, Arts and Humanities, Bacteriology, Biochemistry, Biophysics, and Structural Biology, Biological and Physical Anthropology, Biological Phenomena, Cell Phenomena, and Immunity, Cell and Developmental Biology, Cell Biology, Ecology and Evolutionary Biology, Evolution, Genetic Phenomena, Genetics, Genetics and Genomics, History of Art, Architecture, and Archaeology, Life Sciences, Medical Biochemistry, Medical Cell Biology, Medical Genetics, Medical Immunology, Medical Microbiology, Medical Molecular Biology, Medical Pathology, Medical Sciences, Medicine and Health Sciences, Microbiology, Molecular Biology, Molecular Genetics, Pathogenic Microbiology, Pharmacology, Pharmacology, Toxicology and Environmental Health, Social and Behavioral Sciences, Virology

On May 16, 2020, the Center for Academic Research and Training in Anthropogeny organized the symposium “Impact of Infectious Disease on Humans and Our Origins”. The symposium aimed to gather experts on infectious diseases in one place and discuss the interrelationship between different pathogens and humans in an evolutionary context. The talks discussed topics including SARS-CoV-2, dengue and [...]

  • 1 
search

You can search by:

  • Title
  • Keywords
  • Author Name
  • Author Affiliation