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Somatic evolution of metabolic reprograming: mutation limited or selection limited?
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Authors
Milind Watve 
,
Gayatri Walke
Abstract
Somatic mutations can potentially be responsible for metabolic reprogramming, but the crucial question is whether the evolution would be mutation limited or selection limited. Mathematical and statistical considerations make the case for selection limited evolution stronger, e.g. somatic evolution of cancer is shown to be selection limited than mutation limited. Although some insights are developing into the selection on cancer causing mutations, we have no idea how selection might work on mutations altering metabolic regulation. Therfore the argument for metabolic reprogramming by somatic evolution is only a speculation at present and a focus on selection mechanisms can only make it stronger.
DOI
https://doi.org/10.32942/X28686
Subjects
Life Sciences
Keywords
metabolic reprograming, stem cell, mutation limited, selection limited, somatic evolution
Dates
Published: 2026-08-04 09:34
Last Updated: 2026-08-04 09:34
License
CC BY Attribution 4.0 International
Additional Metadata
Conflict of interest statement:
None
Data and Code Availability Statement:
N.A.
Language:
English
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